abstract：AIM:The balance of excitation and inhibition of neurons and neuronal network is very important to perform complete neuronal function. Damage or loss of inhibitory γ-aminobutyric acid (GABA)-ergic interneuron is associated with impaired inhibitory control of cortical pyramidal neurons, leading to hyperexcitability and e...

journal_title：Journal of the neurological sciences

authors： Sakakibara T,Sukigara S,Otsuki T,Takahashi A,Kaneko Y,Kaido T,Saito Y,Sato N,Nakagawa E,Sugai K,Sasaki M,Goto Y,Itoh M

更新日期：2012-12-15 00:00:00

abstract：:The kynurenine pathway (KP), the primary route of tryptophan degradation in mammalian cells, consists of many metabolites including kynurenic acid (KYNA), quinolinic acid (QUIN), 3-hydroxykynurenine (3-HK) and picolinic acid (PIC). The former two are neuroactive, while the latter two are molecules with pro-oxidants an...

journal_title：Journal of the neurological sciences

authors： Tan L,Yu JT,Tan L

更新日期：2012-12-15 00:00:00

abstract：:Over two decades, a 42-year old woman experienced the gradual onset of choreic involuntary movements, dystonia, and tics. Decreased caudate nucleus metabolism on 2-deoxyglucose PET scan and a heterozygous 49-CAG repeat expansion within the HTT gene established the diagnosis of HD, although no other family history was ...

journal_title：Journal of the neurological sciences

authors： Sidiropoulos C,LeWitt P,Hashimoto K

更新日期：2012-12-15 00:00:00

abstract：:We describe a patient presenting with vertical one-and-a-half syndrome and concomitant contralesional horizontal gaze paresis as the result of a solitary neurocysticercosis (NCC) lesion in the right midbrain extending into the thalamomesencephalic junction. The patient received an albendazole-dexamethasone course whic...

journal_title：Journal of the neurological sciences

authors： Mesraoua B,Deleu D,D'souza A,Imam YZ,Melikyan G

更新日期：2012-12-15 00:00:00

abstract：OBJECTIVE:Cerebrovascular lesions (CVLs) are known to play important roles in the pathophysiology underlying Alzheimer's disease (AD), especially in elderly AD cases. The present study was conducted to elucidate the relationship between the CVLs and vascular risk factors (VRFs) in elderly Japanese patients with AD. SU...

journal_title：Journal of the neurological sciences

authors： Nagata K,Takano D,Yamazaki T,Maeda T,Satoh Y,Nakase T,Ikeda Y

更新日期：2012-11-15 00:00:00

abstract：:Depression is frequently associated with Parkinson disease (PD) but neural basis is still unclear. In previous studies white matter changes present as signal hyperintesities on T2-wighted MRI studies (WMHs) commonly observed in older adults have been associated with depressive symptomatology. In this study we investig...

journal_title：Journal of the neurological sciences

authors： Petrovic IN,Stefanova E,Kozic D,Semnic R,Markovic V,Daragasevic NT,Kostic VS

更新日期：2012-11-15 00:00:00

abstract：:Asia is the most populous region in the world and its rapidly growing societies are the sources of global development. However, accompanying this rapid growth is aging of the population with increasing occurrence of diseases, of which dementia is the most prominent, which provide major challenges to healthcare systems...

journal_title：Journal of the neurological sciences

authors： Catindig JA,Venketasubramanian N,Ikram MK,Chen C

更新日期：2012-10-15 00:00:00

abstract：BACKGROUND:Multiple sclerosis (MS) is a chronic inflammatory demyelinating disorder of the central nervous system. Evidences linking apolipoprotein E (APOE) to myelin repair, neuronal plasticity, and cerebral inflammatory processes suggest that it may be relevant in MS. The main goal of this study was to determine whet...

journal_title：Journal of the neurological sciences

authors： Rafiei M,Zarif Yeganeh M,Sheikholeslami S,Gozalpour E,Ghaffarpour M,Hedayati M

更新日期：2012-09-15 00:00:00

abstract：BACKGROUND:Amyotrophic lateral sclerosis (ALS) is a progressive and fatal disease characterized by progressive degeneration of spinal and bulbar motor neurons. However up to 50% ALS patients may also have cognitive dysfunction which has not been fully examined. METHODS:35 ALS patients [23 patients presenting with limb...

journal_title：Journal of the neurological sciences

authors： Morimoto N,Kurata T,Sato K,Ikeda Y,Sato S,Abe K

更新日期：2012-08-15 00:00:00

abstract：:We report a novel heteroplasmic mutation p.Y440C in the mitochondrial DNA-encoded subunit I of the cytochrome c oxidase (COX) gene in a patient with late onset progressive painless weakness. Her muscle biopsy showed scattered COX-negative fibers and several small collections of inflammatory cells. The mutation was det...

journal_title：Journal of the neurological sciences

authors： Massie R,Wang J,Chen LC,Zhang VW,Collins MP,Wong LJ,Milone M

更新日期：2012-08-15 00:00:00

abstract：BACKGROUND:Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (GNE) myopathy, also called distal myopathy with rimmed vacuoles (DMRV) or hereditary inclusion body myopathy (HIBM), is a rare, progressive autosomal recessive disorder caused by mutations in the GNE gene. Here, we examined the relationship b...

journal_title：Journal of the neurological sciences

authors： Mori-Yoshimura M,Monma K,Suzuki N,Aoki M,Kumamoto T,Tanaka K,Tomimitsu H,Nakano S,Sonoo M,Shimizu J,Sugie K,Nakamura H,Oya Y,Hayashi YK,Malicdan MC,Noguchi S,Murata M,Nishino I

更新日期：2012-07-15 00:00:00

abstract：:Blast-induced neurotrauma (BINT) is a major medical concern yet its etiology is largely undefined. Complement activation may play a role in the development of secondary injury following traumatic brain injury; however, its role in BINT is still undefined. The present study was designed to characterize the complement s...

journal_title：Journal of the neurological sciences

authors： Dalle Lucca JJ,Chavko M,Dubick MA,Adeeb S,Falabella MJ,Slack JL,McCarron R,Li Y

更新日期：2012-07-15 00:00:00

abstract：:Hereditary spastic paraplegia (SPG) is a clinically and genetically heterogeneous group of neurodegenerative disorders that are clinically characterised by progressive spasticity and weakness of the lower-limbs (pure SPG) and, majoritorian, additional more extensive neurological or non-neurological manifestations (com...

journal_title：Journal of the neurological sciences

authors： Finsterer J,Löscher W,Quasthoff S,Wanschitz J,Auer-Grumbach M,Stevanin G

更新日期：2012-07-15 00:00:00

abstract：INTRODUCTION:Palinacousis is a paroxysmal auditory illusion in which perseveration of an external auditory stimulus occurs after cessation of the stimulus. The subjects recognize the illusory nature of this experience, which is often a fragment of the last sentence they heard. Palinacousis has been reported in only a f...

journal_title：Journal of the neurological sciences

authors： Mohamed W,Ahuja N,Shah A

更新日期：2012-06-15 00:00:00

abstract：BACKGROUND/OBJECTIVES:Recently, a genome-wide association study revealed a significant statistical association between LINGO1 rs9652490 and rs11856808 polymorphisms and the risk of developing essential tremor (ET) in Icelandic people. Because the results of further association studies were controversial, we conducted a...

journal_title：Journal of the neurological sciences

authors： Jiménez-Jiménez FJ,García-Martín E,Lorenzo-Betancor O,Pastor P,Alonso-Navarro H,Agúndez JA

更新日期：2012-06-15 00:00:00

abstract：INTRODUCTION:Reports regarding outcome of Guillain-Barré syndrome (GBS) are usually limited to relatively short follow-up. We assessed the occurrence of fatigue and correlated it to clinical measures in patients who had suffered from GBS over 20 years previously. METHODS:We contacted 24 patients with GBS requiring in-...

journal_title：Journal of the neurological sciences

authors： Drory VE,Bronipolsky T,Bluvshtein V,Catz A,Korczyn AD

更新日期：2012-05-15 00:00:00

abstract：:Parkinson's disease (PD) is the second most common form of neurodegeneration in the elderly population. PD is clinically characterized by tremors, rigidity, slowness of movement and postural imbalance. A significant association has been demonstrated between PD and low levels of thiamine in the serum, which suggests th...

journal_title：Journal of the neurological sciences

authors： Lu'o'ng Kv,Nguyên LT

更新日期：2012-05-15 00:00:00

abstract：:Central nervous system (CNS) vasculitis is a rare group of disorders that affect vessels of the brain parenchyma and meninges. It presents with headache, cognitive changes, or seizures, yet without aggressive management, it carries a high degree of morbidity and mortality. Refractory status epilepticus (SE) has been r...

journal_title：Journal of the neurological sciences

authors： Atkinson M,Atkinson B,Norris G,Shah A

更新日期：2012-04-15 00:00:00

abstract：:Clinical awakening can be seen just before or after seizure onsets. In this study we determined the time between onset of seizures and awakening in patients with frontal lobe epilepsy (FLE) and temporal lobe epilepsy (TLE). Sixty-eight patients who underwent video-EEG monitoring with simultaneous PSG were retrospectiv...

journal_title：Journal of the neurological sciences

authors： Yildiz FG,Tezer FI,Saygi S

更新日期：2012-04-15 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by loss of motor neuron and various cognitive deficits including writing errors. (11)C-flumazenil (FMZ), the positron emission tomography (PET) GABA(A) receptor ligand, is a marker of cortical dysfunction. The objective of this study was...

journal_title：Journal of the neurological sciences

authors： Yabe I,Tsuji-Akimoto S,Shiga T,Hamada S,Hirata K,Otsuki M,Kuge Y,Tamaki N,Sasaki H

更新日期：2012-04-15 00:00:00

abstract：:Propriospinal myoclonus (PSM) is a rare movement disorder characterized by involuntary axial jerks originating from muscles innervated by multiple spinal segments. Most cases of PSM are idiopathic. Gluten sensitivity is a multisystemic autoimmune condition which may be associated with various neurological disorders, m...

journal_title：Journal of the neurological sciences

authors： Zhang Y,Menkes DL,Silvers DS

更新日期：2012-04-15 00:00:00

abstract：BACKGROUND:A recent pilot study suggested spasticity improvement during glatiramer acetate (GA) treatment in multiple sclerosis (MS) patients who previously received interferon-β (IFN-β). OBJECTIVE:To evaluate changes in spasticity in MS patients switching from IFN-β to GA. METHODS:Observational, multicentre study in...

journal_title：Journal of the neurological sciences

authors： Meca-Lallana JE,Balseiro JJ,Lacruz F,Guijarro C,Sanchez O,Cano A,Costa-Frossard L,Hernández-Clares R,Sanchez-de la Rosa R,Escala Study Group.

更新日期：2012-04-15 00:00:00

abstract：BACKGROUND:The aims of this paper are: 1) to present the data of systemic thrombolysis for ischemic stroke in five Croatian centers from July 2008 till January 2010; 2) to compare the results between centers and; 3) to compare data with previously published results from 2006 to 2008 period from our center, and with the...

journal_title：Journal of the neurological sciences

authors： Matijević V,Poljaković Z,Malojčić B,Mišmaš A,Bazina A,Boban M,Bilić I,Radanović B,Glavor KD,Kiđemet-Piskač S,Habek M

更新日期：2012-03-15 00:00:00

abstract：BACKGROUND:The treatment of hypertension is an essential component of stroke prevention; however, the clinical management of patients with cerebrovascular disease is complicated by orthostatic hypotension (OH). The primary objectives were to: determine the prevalence of OH in a stroke outpatient clinic; describe catego...

journal_title：Journal of the neurological sciences

authors： Phipps MS,Schmid AA,Kapoor JR,Peixoto AJ,Williams LS,Bravata DM

更新日期：2012-03-15 00:00:00

abstract：BACKGROUND:Interleukin 17 (IL-17) plays an important role in many autoimmune diseases including neuromyelitis optica (NMO) and multiple sclerosis (MS), which are inflammatory demyelinating diseases of the central nervous system. A large number of non-HLA single nucleotide polymorphisms have been reported to increase th...

journal_title：Journal of the neurological sciences

authors： Wang H,Zhong X,Wang K,Qiu W,Li J,Dai Y,Hu X

更新日期：2012-03-15 00:00:00

abstract：:The present study was performed to investigate the effects of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) antisense oligodeoxynucleotides (ODNs) on the assembly of the CaMKII·GluR6·PSD-95 signaling module, GluR6 serine phosphorylation and c-Jun N-terminal kinase 3 (JNK3) activation. A further aim was to det...

journal_title：Journal of the neurological sciences

authors： Liu Z,Xu J,Shen X,Lv C,Xu T,Pei D

更新日期：2012-03-15 00:00:00

abstract：BACKGROUND:Intravenous rt-PA is effective in hyperacute ischemic stroke (HAIS) but is administered only in few patients. OBJECTIVES:To report the thrombolysis rate in our stroke unit using a stroke code (SC) protocol with a prenotification system and to analyze the SC impact on the thrombolysis rate in a systematic re...

journal_title：Journal of the neurological sciences

authors： Dalloz MA,Bottin L,Muresan IP,Favrole P,Foulon S,Levy P,Drouet T,Marro B,Alamowitch S

更新日期：2012-03-15 00:00:00

abstract：:We have determined various biomarkers in the peripheral blood of Alzheimer, Parkinson and vascular dementia patients by comparing the samples with those of first-degree relatives and control subjects. Our results, together with correlation studies using data from the Mini-Mental State Examination (MMSE), suggest that ...

journal_title：Journal of the neurological sciences

authors： Cristalli DO,Arnal N,Marra FA,de Alaniz MJ,Marra CA

更新日期：2012-03-15 00:00:00

abstract：:There is evidence that visuo-spatial capacity can become overloaded when processing a secondary visual task (Dual Task, DT), as occurs in daily life. Hence, we investigated the influence of the visuo-spatial interference in the identification of emotional facial expressions (EFEs) in early stages of Parkinson's diseas...

journal_title：Journal of the neurological sciences

authors： García-Rodríguez B,Guillén CC,Barba RJ,io Valladolid GR,Arjona JA,Ellgring H

更新日期：2012-02-15 00:00:00

abstract：:Reversible cerebral vasoconstriction syndrome (RCVS) is characterized by segmental vasoconstriction and dilatation of intracranial arteries, usually revealed by headaches, which spontaneously resolve in few weeks. We report a patient with RCVS, revealed by thunderclap headaches, involving both internal and external ca...

journal_title：Journal of the neurological sciences

authors： Melki E,Denier C,Théaudin-Saliou M,Sachet M,Ducreux D,Saliou G

更新日期：2012-02-15 00:00:00

abstract：:Superficial siderosis (SS) of the central nervous system is a rare disorder caused by chronic or recurrent hemorrhages into the subarachnoid space with hemosiderin and ferritin deposition, which leads to neuronal damage. The source of bleeding remains unknown in 50% of cases. Recently, attention has been focused on fl...

journal_title：Journal of the neurological sciences

authors： Boncoraglio GB,Ballabio E,Erbetta A,Prada F,Savoiardo M,Parati EA

更新日期：2012-01-15 00:00:00

abstract：PURPOSE:To investigate the presence of an ethnicity bias within patients presenting with optic neuritis in London. DESIGN:Observational cross-sectional study. METHODS:The ethnicity profile of all patients attending a neuro-ophthalmology clinic in central London with acute optic neuritis over a 16month period (n=86) w...

journal_title：Journal of the neurological sciences

authors： Storoni M,Pittock SJ,Weinshenker BG,Plant GT

更新日期：2012-01-15 00:00:00

abstract：:In the last two decades functional magnetic resonance imaging (fMRI) has dominated research in neuroscience. However, only recently has it taken the first steps in translation to the clinical field. In this paper we describe the advantages of fMRI and DTI and the possible benefits of implementing these methods in clin...

journal_title：Journal of the neurological sciences

authors： Bick AS,Mayer A,Levin N

更新日期：2012-01-15 00:00:00

abstract：:Here we report a case with positive serum anti-aquaporin 4 (AQP4) antibody who presented with hypersomnolence, symmetrical hypothalamic lesions and a reduced CSF orexin (hypocretin) level without optic nerve and spinal cord lesions on MRI. All of the symptoms, MRI finding and CSF orexin level improved simultaneously a...

journal_title：Journal of the neurological sciences

authors： Deguchi K,Kono S,Deguchi S,Morimoto N,Ikeda M,Kurata T,Ikeda Y,Matsuura T,Kanbayashi T,Takahashi T,Abe K

更新日期：2012-01-15 00:00:00

abstract：INTRODUCTION:Embryo-derived PIF modulates systemic maternal immunity without suppression. Synthetic analog (sPIF) prevents juvenile diabetes, preserves islet function, reducing oxidative stress/protein misfolding. We investigate sPIF effectiveness in controlling neuroinflammation/MS. METHODS:Examine sPIF-induced prote...

journal_title：Journal of the neurological sciences

authors： Weiss L,Or R,Jones RC,Amunugama R,JeBailey L,Ramu S,Bernstein SA,Yekhtin Z,Almogi-Hazan O,Shainer R,Reibstein I,Vortmeyer AO,Paidas MJ,Zeira M,Slavin S,Barnea ER

更新日期：2012-01-15 00:00:00

abstract：:Multiple sclerosis is a chronic inflammatory disease of the white and grey matter which results in irrevocable axonal and neuronal damage. Grey matter injury is widespread and reflects disability to a greater extent than do white matter lesions. Growing understanding of the immunopathology of multiple sclerosis is lea...

journal_title：Journal of the neurological sciences

authors： Meinl E

更新日期：2011-12-01 00:00:00

abstract：INTRODUCTION:Cognitive impairment and depressive symptoms caused by Parkinson's disease (PD) are often underestimated in routine clinical practice, partly due to the lack of short screening tests. The "Parkinson Neuropsychometric Dementia Assessment" (PANDA) is a new convenient tool, validated in German, to assess cogn...

journal_title：Journal of the neurological sciences

authors： Gasser AI,Kalbe E,Calabrese P,Kessler J,Von Allmen G,Rossier P

更新日期：2011-11-15 00:00:00

abstract：:Theory of Mind is an important concept within social cognition and refers to the ability to attribute mental states to oneself and others. Other terms for this concept include mentalizing and mind reading. Deficits in Theory of Mind may contribute to behavioral abnormalities, such as paranoia and delusions that are co...

journal_title：Journal of the neurological sciences

authors： Freedman M,Stuss DT

更新日期：2011-11-15 00:00:00

abstract：:Somatoform Disorders (SFMD) were recently described in Parkinson Disease (PD) and Dementia with Lewy Bodies (DLB). The present paper updates the observations in our cohort of patients and further details clinical phenomenology. Of 3178 patients consecutively referred to our Institutions from 1999, 1572 subjects had ne...

journal_title：Journal of the neurological sciences

authors： Onofrj M,Thomas A,Tiraboschi P,Wenning G,Gambi F,Sepede G,Di Giannantonio M,Di Carmine C,Monaco D,Maruotti V,Ciccocioppo F,D'Amico MC,Bonanni L

更新日期：2011-11-15 00:00:00

abstract：:Though the core symptoms of Parkinson's disease (PD) are motor-related, a majority of patients also have neuropsychiatric symptoms concerning mood, behavior and cognition. Apathy and depression are considered among the most frequent ones, and have a negative impact on global functioning and quality of life. Recent neu...

journal_title：Journal of the neurological sciences

authors： Benoit M,Robert PH

更新日期：2011-11-15 00:00:00